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慢性病中的乌比基特异蛋白18-另一个需要考虑的新兴生物标志物?

Paulina Dziamałek-Macioszczyk¹, Agata Winiarska¹, Anna Pawłowska¹

¹Department of Nephrology, Hypertension and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-561 Olsztyn, Poland.

|May 25, 2024

概括

在慢性病 (CKD) 中,乌比基特异性蛋白酶18 (USP18) 水平下降,这表明心脏保护信号受损. 增加尿路USP18可能表明管损伤.

科学领域:

生物化学生物化学
腎臟病學 (nephrology) 是一種醫學專業.
心脏病学心脏病学

背景情况:

乌比基特异蛋白酶18 (USP18) 是一种具有双重功能的蛋白质,影响细胞循环和信号传递.
USP18在应对增加后负载时抑制心脏重塑方面发挥作用.
在病理中USP18的参与尚未得到充分理解.

研究的目的:

调查血清和尿液USP18水平与心血管风险因素之间的关系.
评估USP18水平与慢性病 (CKD) 的各个阶段的病活动相关.

主要方法:

这项研究包括100名参与者,分为五组:健康的蛋白尿性淋巴结核炎,非蛋白尿性CKD,血液透析和移植接受者.
血清和尿液USP18水平使用ELISA量化.
在USP18水平和功能标志物之间进行了相关性分析.

主要成果:

血清USP18水平在健康个体和脏移植接受者中最高,在CKD患者中较低.
尿中USP18水平在尚未透析的CKD患者中最高.
尿路USP18与非透析CKD患者的血清肌素和尿素相关.

结论:

功能障碍可能会抑制USP18.的心脏保护信号.
尿中USP18水平升高可能作为慢性管损伤的生物标志物.

关键词:

专辑蛋白尿症是什么意思进行心脏重塑.慢性心力衰竭是一种慢性心力衰竭.慢性脏疾病慢性脏疾病没有二维基因酸酶.蛋白质尿症是一种蛋白质尿症.基特异性蛋白酶18的存在

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