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Updated: Jun 25, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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胺三甲衍生物作为人类二叶酸减少酶抑制剂-分子建模和体外活性研究

Danuta Drozdowska1, Agnieszka Wróbel-Tałałaj1, Cezary Parzych2

  • 1Department of Organic Chemistry, Medical University of Białystok, Mickiewicza Street 2A, 15-222 Białystok, Poland.

Biomedicines
|May 25, 2024
PubMed
概括

新的胺衍生物显示出人类二叶酸减少酶 (hDHFR) 的强烈抑制,这是癌症治疗的关键标. 化合物JW2和JW8表现出有前途的活性和酶稳定性,这表明它们有可能成为新型治疗药物.

关键词:
作为DHFR抑制剂的使用.它具有抗癌活性,具有抗癌活性.班扎米德是一种本扎米德.药物设计 药物设计三甲胺衍生物三甲胺衍生物

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