射频治疗减轻了动物皮肤皮肤皮肤外皮连接处与年龄相关的变化
Kyung-A Byun1,2,3, Hyoung Moon Kim4, Seyeon Oh3
1Department of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea.
International journal of molecular sciences
|May 25, 2024
概括
射频 (RF) 治疗通过增强热冲击蛋白 (HSP) 和激活Piezo1.1,使皮肤再生. 这增强皮肤-表皮结 (DEJ) 蛋白质和结构,抵制与年龄相关的皮肤变化.
科学领域:
- 皮肤病学 皮肤病学
- 细胞生物学 细胞生物学
- 生物医学工程 生物医学工程
背景情况:
- 皮肤-表皮结 (DEJ) 对皮肤完整性至关重要,并且受到老化的影响.
- 射频 (RF) 治疗是一种有前途的皮肤再生方法.
- 已知RF可刺激原蛋白生产,热冲击蛋白 (HSP),并激活Piezo1,一种参与M2巨分极和TGF-β生产的离子通道.
研究的目的:
- 调查射频对HSP47和HSP90表达的影响,这是DEJ蛋白的关键刺激剂.
- 评估RF诱导的Piezo1激活和M2极化是否可以逆转与年龄相关的DEJ恶化.
- 评估RF对老年皮肤模型中DEJ结构和蛋白质表达的影响.
主要方法:
- 在实验室中使用H2O2诱导的衰老角质细胞和巨细胞进行的研究.
- 在衰老纤维细胞上对RF处理的衰老巨细胞的条件介质进行分析.
- 在用RF治疗的老年动物皮肤模型上的体内研究.
主要成果:
- 射频处理在衰老的角质细胞中调高了HSP47,HSP90,TGF-β和DEJ蛋白 (例如原XVII).
- 射频治疗增加了老化的巨细胞中的Piezo1和M2标记物 (CD206).
- 射频增强了DEJ蛋白表达,增加了表皮厚度,改善了老年动物皮肤中的DEJ结构完整性,同时减少了薄膜密度复制和损伤损伤.
结论:
- 射频治疗有效地增强皮肤-表皮交叉蛋白质的表达.
- 射频通过增加HSP水平和激活Piezo1.1来缓解与年龄相关的DEJ结构损伤.
- 射频诱导的Piezo1激活和M2极化通过改善DEJ完整性,有助于皮肤再生.
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