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年轻患者头状细胞癌中EZH2表达

Mónika Révész¹, Ferenc Oberna¹, András Slezák²

¹Multidisciplinary Head and Neck Cancer Center, National Institute of Oncology, H-1122 Budapest, Hungary.

International journal of molecular sciences

|May 25, 2024

概括

年轻的头角状细胞癌 (HNSCC) 患者与老年患者相比,表达较低的Enhancer of zeste homolog 2 (EZH2) 表达. 这一发现表明患者的特征,而不是瘤恶性,驱动早期发病的HNSCC,并可能影响抗EZH2治疗的疗效.

科学领域:

在瘤学瘤学.
分子生物学分子生物学

背景情况:

增强质同源2 (EZH2) 是一个关键的表观遗传调节器,与瘤进展有关,是癌症治疗的标.
头角状细胞癌 (HNSCC) 可以影响所有年龄段的患者,根据发病年龄,瘤生物学可能存在差异.

研究的目的:

研究和比较年轻HNSCC患者瘤中的EZH2表达水平与一般HNSCC患者.
评估EZH2表达与年轻HNSCC患者的患者特征或生存结果之间的相关性.

主要方法:

免疫组织化学染色用于检测瘤组织样本中的EZH2和p53表达.
来自年轻HNSCC患者 (≤39岁) 的甲固定,嵌组织与来自一般HNSCC患者的年龄和性别匹配的对照进行了比较.
统计分析,包括曼-惠特尼测试和考克斯回归,用于比较表达水平和确定死亡率预测因素.

主要成果:

与一般的HNSCC患者相比,来自年轻HNSCC患者的瘤表现出明显较低的EZH2表达强度和较低的阳性瘤细胞比例.
晚期T阶段,阳性结节状况和酒精消费与年轻HNSCC患者的死亡率有关.
内EZH2和p53表达水平都没有预测年轻患者队列中的死亡率.

结论:

年轻HNSCC患者的EZH2表达减少并不表明更具侵略性的瘤表型,而是突出了患者特定因素的影响.
这些发现表明,新型抗EZH2疗法的疗效可能在年轻的HNSCC患者中不同,需要进一步调查.

关键词:

在 EZH2 中使用.这是头癌症.预后因素预后因素年轻的成年人年轻的成年人

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