相关实验视频

Updated: Jun 25, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

骨肉瘤中的甘氨酸结构作为基于莱克的化学抗原受体免疫疗法的点

Nele Prasse¹, Charlotte Wessolowski¹, Ingo Müller^1,2

¹Research Institute Children's Cancer Center Hamburg, 20251 Hamburg, Germany.

International journal of molecular sciences

|May 25, 2024

概括

研究人员探索了CD301连接体作为骨髓瘤免疫治疗的点. 这种以莱克为基础的方法显示出治疗骨癌的潜力,特别是当与像TIGIT这样的免疫检查点抑制剂相结合时.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
葡萄糖生物学葡萄糖生物学

背景情况:

骨肉瘤影响儿童和年轻人,复发或转移病例的存活率较低.
目前的治疗方法对晚期骨髓瘤的疗效有限.
针对癌细胞上的特定分子结构是有前途的免疫疗法策略.

研究的目的:

研究CD301连接体作为骨髓瘤免疫治疗的潜在标.
为了评估CD301-CAR NK92细胞对骨髓瘤的疗效.
评估CD301-CAR NK92细胞和TIGIT抑制的联合治疗.

主要方法:

通过重组CD301 (MGL,CLEC10A) 染色原发性骨髓瘤组织.
在体外评估CD301-CAR NK92细胞介导的细胞毒性对骨髓瘤细胞.
测试NK细胞降粒和细胞因子释放.
结合疗法研究涉及CD301-CAR和抗TIGIT抗体.

主要成果:

在原发性骨髓瘤瘤的一个子集 (26%) 中表达了CD301连接体.
在实验室中,CD301-CAR NK92细胞表现出识别和消除骨髓瘤细胞.
细胞毒性活性与增强的脱粒和细胞因子释放相关.
与TIGIT抑制的结合产生了额外的治疗效益.

结论:

CD301连接体代表了骨髓瘤中基于莱克的免疫疗法的新目标结构.
CD301-CAR NK92细胞显示出对骨髓瘤的治疗潜力.
结合CD301和TIGIT的向可能会改善骨髓瘤患者的治疗结果.

关键词:

CD301 (MGL,CLEC10A) 是一个类型.在Tn/STn抗原.仿制性抗原受体的仿制性抗原受体免疫检查点抑制抑制免疫检查点抑制免疫疗法免疫疗法骨质肉瘤是骨质肉瘤的一种疾病.

更多相关视频

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

Published on: October 1, 2009

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

相关概念视频

Proteoglycans

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.