基于植物化学的局部应用在治疗湿疹的最新进展:一篇综述
Janani Radhakrishnan1, Barry E Kennedy2, Erin B Noftall2
1Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada.
International journal of molecular sciences
|May 25, 2024
概括
来自植物的植物化学物质在治疗湿疹 (皮炎) 中表现有前途. 这些通过先进载体输送的天然化合物可以改善皮肤屏障功能并减少炎症,为传统疗法提供更安全的替代方案.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 湿疹 (atopic dermatitis,AD) 是一种慢性皮肤疾病,其特征是皮肤屏障功能受损.
- 目前的治疗方法,如皮质类固醇和氨酸抑制剂,有潜在的长期副作用.
- 植物化学物质为开发新型局部AD治疗提供了潜在的途径.
研究的目的:
- 审查基于植物化学品的局部应用在治疗阿托皮性皮肤炎的最新进展.
- 讨论各种载体在提高这些天然化合物的疗效方面的作用.
- 探索植物化学品在缓解与传统AD疗法相关的副作用方面的潜力.
主要方法:
- 对阿尔茨海默病的植物提取物和植物化学品的临床研究和临床前数据的审查.
- 基于SCORAD指数,表皮厚度和跨皮肤水损失的疗效分析.
- 对纳米载体系统 (脂质体,乙体,纳米乳液等) 的检查. 用于局部交付.
主要成果:
- 植物化学物质表现出抗皮作用,改善了临床评分和皮肤屏障参数.
- 在体内研究显示,炎症标志物 (TSLP,IgE,ILs) 减少,费拉格林 (FLG) 基因表达增加.
- 各种纳米载体增强了用于局部AD治疗的植物化学品的输送和生物可用性.
结论:
- 以植物化学物质为基础的局部治疗显示出管理亚托邦性皮炎的巨大潜力.
- 先进的纳米载体系统可以优化这些天然化合物的输送和有效性.
- 自然局部治疗可能提供更安全的替代方案,降低传统疗法不良影响的风险.
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