化学物质作为结直肠癌患者的预后因素:系统性审查和元分析
Johanna Fellhofer-Hofer1, Clemens Franz1, Johannes A Vey2
1Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, Germany.
International journal of molecular sciences
|May 25, 2024
概括
化基因受体CXCR4过度表达表明结直肠癌患者的预后不佳,显著降低整体和无疾病生存率. 这一系统性审查强调了CXCR4作为结直肠癌的潜在预后生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 化基因及其受体是瘤进展的组成部分,影响血管新生,亡和转移.
- 瘤透免疫细胞和瘤细胞在瘤微环境中表达化学因受体.
- 改变的化学激素和受体表达在固体癌症中很常见,影响患者的结果,特别是在结直肠癌中.
研究的目的:
- 系统地审查和元分析化基因作为结直肠癌 (CRC) 中预后生物标志物的作用.
- 调查25种特定化学因子的表达与CRC患者生存结果之间的关联.
主要方法:
- 在PubMed,CENTRAL和Web of Science数据库中进行了系统的文献搜索.
- 包括来自31个出版物的数据,分析CRC组织和患者存活率中的化学激素表达.
- 总生存期 (OS) 和无病生存期 (DFS) 的危险比率 (HR) 用随机效应元分析计算,偏差风险通过预后研究质量评估.
主要成果:
- 化学基因受体CXCR4的过度表达与CRC患者的总生存时间 (HR = 2.70) 和无病生存时间 (HR = 2.68) 的减少显著相关.
- 对评估CXCR4的研究的偏差风险被评为低.
- 其他化学因子的结果是异质的或基于有限的研究.
结论:
- 过度表达CXCR4是结直肠癌患者总体和无病生存率下降的重要指标.
- CXCR4成为结直肠癌的一个有前途的预后生物标志物.
- 需要进一步的研究来探索CXCR4及其对抗剂作为CRC的潜在治疗点.
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