肠-大脑轴:专注于神经炎症中的性别差异
Mario Caldarelli1, Pierluigi Rio1, Andrea Marrone1
1Department of Translational Medicine and Surgery, Catholic University of Rome, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.
International journal of molecular sciences
|May 25, 2024
概括
肠-大脑轴将肠道微生物与大脑健康联系起来. 微生物失衡 (失生症) 可以引起神经炎症,影响神经系统功能,并可能导致大脑疾病.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 对肠-大脑轴及其在健康和疾病中的作用越来越感兴趣.
- 肠道微生物失调症越来越多地与与大脑有关的疾病有关.
- 失生症会破坏肠道屏障,引发免疫反应和神经炎症.
研究的目的:
- 审查神经炎症的分子机制.
- 详细介绍肠-大脑轴,重点关注微生物代谢产物.
- 突出性对这些机制的影响.
主要方法:
- 现有文献的叙述性审查.
- 分析涉及神经炎症的分子通路.
- 检查肠道微生物代谢物及其神经影响.
- 在肠-大脑轴上包括基于性别的差异.
主要成果:
- 肠-大脑轴由炎症,免疫,神经递质和神经内分泌路径介导.
- 肠道微生物代谢物可以影响神经系统功能.
- 性激素在多个层面 (CNS,ENS,肠内分泌细胞) 调节肠-大脑轴.
结论:
- 了解肠-大脑轴对于诊断和治疗与大脑有关的疾病至关重要.
- 肠-大脑轴的性别特异性需要进一步研究.
- 准肠道微生物组为神经系统疾病提供了潜在的治疗策略.
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