血蛋白与波多黎各的COVID-19严重程度有关
Lester J Rosario-Rodríguez1, Yadira M Cantres-Rosario2, Kelvin Carrasquillo-Carrión3
1Department of Microbiology and Medical Zoology, University of Puerto Rico, Medical Sciences Campus, San Juan 00935, Puerto Rico.
International journal of molecular sciences
|May 25, 2024
概括
患有严重COVID-19的波多黎各人表现出独特的宿主蛋白质变化,包括较低的Cadherin-13和TNF-α. 这可以预测疾病的严重程度,并为这一群体指导新的治疗方法.
科学领域:
- 基因组学和蛋白质组学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 宿主因素,病毒菌株和年龄影响SARS-CoV-2免疫反应和COVID-19的严重程度.
- 波多黎各人拥有独特的遗传混合物 (欧洲人,非洲人,美洲原住民).
- 了解宿主特定因素对于预测不同人群中COVID-19结果至关重要.
研究的目的:
- 研究与波多黎各人COVID-19疾病严重程度相关的独特宿主蛋白质和途径.
- 为了确定潜在的生物标志物来预测严重的COVID-19在这个人群.
主要方法:
- 从95名参与者 (39名COVID-19阳性,56名阴性) 的血样本上使用双重质量标签 (TMT) 标签的定量蛋白质组学.
- 根据症状学,COVID-19患者分为轻度,中度和重度的分层.
- 使用LC/MS/MS,蛋白质组发现器,LIMA软件,英才途径分析 (IPA) 和细胞因子免疫测试进行分析.
主要成果:
- 蛋白质组学在严重的COVID-19病例中确定了58种差异表达的蛋白质.
- 参与突触发生的卡德-13,在重症患者中下调,并通过ELISA验证.
- 瘤坏死因子-α (TNF-α) 水平随着COVID-19疾病严重程度的增加而下降.
结论:
- 这项研究揭示了波多黎各人中COVID-19严重程度的潜在宿主蛋白预测因素.
- 这些发现表明了新的治疗点,并强调了遗传背景对疾病结果的重要性.
- 卡德林-13和TNF-α作为COVID-19严重程度的生物标志物需要进一步调查.
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