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Updated: Jun 16, 2026

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
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利用基于细胞的测试来加速对G蛋白结合受体的药物开发

Yuxin Wu1,2, Niels Jensen2,3, Moritz J Rossner2,3

  • 1Research Group Cell Signalling, Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Nussbaumstr. 7, 80336 Munich, Germany.

International journal of molecular sciences
|May 25, 2024
PubMed
概括

基因编码的基于细胞的测试,包括多重格式,为测量G蛋白结合受体 (GPCR) 活性提供了强大的工具. 这些测试通过全面识别化合物对GPCR信号通路的影响,加速药物发现.

关键词:
在GPCR中,GPCR是指GPCR.在GPCR工程方面,基于细胞的测定.发现药物的发现.药物查对药物进行查.

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相关概念视频

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...