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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

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In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
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Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

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Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
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Hormonal Regulation01:33

Hormonal Regulation

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The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
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Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

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Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
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相关实验视频

Updated: Jun 25, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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长非编码RNA MALAT1:盐敏感高血压

Mohd Mabood Khan1, Annet Kirabo1

  • 1Department of Medicine, Preston Research Building, Vanderbilt University Medical Centre, Nashville, TN 37232, USA.

International journal of molecular sciences
|May 25, 2024
PubMed
概括

高盐摄入导致高血压,通过通过上皮质通道增加氧化应激. 长非编码RNAMALAT1通过上调Keap1来加剧这种情况,抑制抗氧化剂Nrf2通路. 抑制MALAT1可以治疗高血压.

科学领域:

  • 心血管科学 心血管科学
  • 分子生物学分子生物学
  • 免疫学 免疫学 免疫学

背景情况:

  • 高血压是全球死亡的主要原因,与心血管疾病有关.
  • 增加盐的摄入量通过抗原呈现细胞 (APC) 促进炎症和高血压.
  • 氧化应激,脂质过氧化,和isolevuglandin形成是关键的炎症媒介.

研究的目的:

  • 探索长非编码RNAMALAT1在Keap1-Nrf2-抗氧化剂防御途径中在盐引起的高血压中的作用.
  • 研究MALAT1作为高血压和心血管疾病治疗点的潜力.

主要方法:

  • 研究了皮质通道 (ENaC) 在诱导的APC激活和氧化应激中的作用.
  • 研究了对MALAT1表达的调节及其对Keap1和Nrf2.2的影响.
  • 评估了MALAT1沉默对诱导的Keap1上调和Nrf2核转移的影响.

主要成果:

  • 摄入通过ENaC激活APC,增加氧化应激和炎症.
  • 马拉特1的表达通过Sp1由上调,导致Keap1的增加和抑制Nrf2.
  • 沉默MALAT1逆转诱导的Keap1上调,促进Nrf2活性和抗氧化基因表达.
关键词:
马拉特语 马拉特语这种高血压,高血压.这是一种炎症炎症炎症炎症.长非编码RNA是什么意思盐 盐 盐 盐 盐 盐 盐 盐 盐

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结论:

  • 通过Keap1-Nrf2通路,MALAT1调节高血压中的抗氧化防御.
  • 抑制MALAT1为盐引起的高血压和心血管疾病提供了潜在的治疗策略.