在绝经后骨质疏松和心血管疾病的发病过程中具有共同作用的转录的识别
Sjur Reppe1,2,3, Sveinung Gundersen4, Geir K Sandve5
1Department of Medical Biochemistry, Oslo University Hospital, 0450 Oslo, Norway.
International journal of molecular sciences
|May 25, 2024
概括
研究人员确定了50个在绝经后骨质疏松症 (OP) 和心血管疾病 (CVD) 之间共享的基因,为这些疾病和潜在的治疗点之间的生物联系提供了新的见解.
科学领域:
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 流行病学研究表明,绝经后骨质疏松症 (OP) 和心血管疾病 (CVD) 之间存在联系.
- 导致这种共同疾病的特定共享遗传因素在很大程度上仍未确定.
研究的目的:
- 在绝经后的妇女中识别骨质疏松症和心血管疾病之间的共享基因.
- 探索OP和CVD之间的关联背后的生物机制和途径.
主要方法:
- 使用微芯片和RNA测序,分析绝经后妇女骨活检中的骨全球转录组.
- 对1000个与面积骨矿物质密度 (aBMD) 相相关的转录进行生物信息分析,以确定与心血管疾病相关基因的重叠.
- 应用基因类型知情条件错误发现率方法来验证SNP重叠.
主要成果:
- 发现了50个基因 (45个mRNA,5个miRNA) 在氧化应激,炎症,内皮功能,纤维化,脱脂症和骨质母细胞生成/化中发挥作用.
- 这些类基因在内皮细胞和心肌细胞中发现,并且在骨质疏松妇女中差异地表达.
- 基因分析证实了与aBMD和CVD相关的基因之间的SNP重叠.
结论:
- 这项研究提供了转录和基因组证据,证明BMD调节和绝经后骨中心血管疾病风险之间的共享基因.
- 识别的转录为了解CVD-OP关联的机制基础提供了新的途径.
- 这些发现可能会导致针对这两种疾病的新治疗策略.
相关概念视频
Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Menopause
155
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
155
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Regulated Protein Degradation
2.5K
2.5K


