提高EQ-5D-5L在捕捉COVID-19后患者中最常见的症状中的敏感性:一项探索性横截面研究,重点关注疲劳,记忆/集中力问题和呼吸障碍维度
Helena Janols1, Carl Wadsten2, Christoffer Forssell3,4
1Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, 751 85 Uppsala, Sweden.
概括
EQ-5D-5L工具部分捕捉了COVID-19后患者的疲劳和记忆问题,但与呼吸障碍作斗争. 增加疲劳显著提高了该工具解释与健康相关的生活质量的能力.
科学领域:
- 健康 结果 研究 研究 结果
- 衡量生活质量 衡量生活质量
- 后COVID条件 后COVID条件
背景情况:
- 疲劳,记忆障碍和呼吸障碍等持续症状在COVID-19后的情况中很常见.
- 准确评估这些症状对于理解与健康相关的生活质量 (HRQoL) 至关重要.
- EQ-5D-5L是衡量HRQoL的广泛使用的工具,但其捕捉特定COVID-19后症状的能力需要评估.
研究的目的:
- 评估EQ-5D-5L工具是否能够充分捕捉COVID-19后患者常见的持续症状.
- 要确定是否包括这些特定症状可以提高EQ-5D-5L对HRQoL的解释能力.
- 调查疲劳,记忆/集中力问题和呼吸障碍对EQ-5D-5L视觉模拟量表 (EQ-VAS) 成绩的影响.
主要方法:
- 一项探索性横截面研究,涉及177名瑞典患者,他们有COVID-19病史.
- 患者使用EQ-5D-5L和EQ-VAS.填写了有关社会人口统计因素,临床因素和HRQoL的问卷.
- 使用斯皮尔曼等级相关性和多重回归分析来评估症状捕捉和解释能力.
主要成果:
- EQ-5D-5L解释了47%的疲劳和55%的记忆/注意力问题的变异,但只有14%的呼吸障碍.
- 将疲劳添加到EQ-5D-5L模型中,使EQ-VAS得分的解释变异增加了5.7%.
- 添加记忆/集中力问题和呼吸障碍对解释差异的影响较小.
结论:
- 在COVID-19后的患者中,EQ-5D-5L在捕捉疲劳和记忆/集中力问题方面表现出强项.
- 该工具在评估这种患者群体的呼吸障碍方面存在局限性.
- 疲劳是一个显著的症状,显著提高了EQ-5D-5L在COVID-19后的个人中预测整体HRQoL的能力.
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