在自主造血干细胞采集中,动员相关因素较差
Won Kee Ahn1, Hyun-Jun Nam2, Hae Won Lee1
1Division of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Yonsei University Health System, Seoul 03722, Republic of Korea.
Cancers
|May 25, 2024
概括
成功的外周血液干细胞移植 (PBSCT) 需要充分的CD34+细胞动员. 这项研究确定了血液病与非血液病疾病动员不良的不同风险因素,强调了需要量身定制的策略.
科学领域:
- 血液学 血液学 血液学
- 移植免疫学 移植免疫学
- 细胞疗法细胞疗法
背景情况:
- 周围血液干细胞移植 (PBSCT) 对于治疗各种疾病至关重要.
- 充分调动和采集CD34+细胞对于成功的PBSCT结果至关重要.
- 关于非血液病中的动员挑战和用于plerixa的有限数据存在.
研究的目的:
- 为了识别与CD34+细胞动员不良在自主PBSC收获 (PBSCH) 期间相关的风险因素.
- 为了比较血液病和非血液病患者之间的动员风险因素.
- 为了评估接受plerixafor.com的患者的动员结果.
主要方法:
- 对来自491名患者的自主PBSC收获数据的回顾性分析.
- 多变量分析以确定与CD34+细胞动员不良相关的因素.
- 基于疾病类型 (血液病与非血液病) 和plerixa的使用的分析分层.
主要成果:
- 在血液学疾病中,年龄较大 (>60岁),髓毒药物和血小板数量低预测了动员能力较差.
- 在非血液性疾病中,先前的骨盆/脊柱辐射是动员不良的唯一重要因素.
- 在plerixafor接受者中,14.2%的受试者动员不良,在良好的动员组中观察到治疗方案的变化.
结论:
- 患有CD34+细胞动员不良的危险因素在血液病患者和非血液病患者之间有显著差异.
- 非血液病患者需要特别考虑,以获得成功的PBSCH.
- 需要对与plerixafor相关的动员进行进一步的调查.
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