免疫疗法作为肝细胞癌外科治疗的补充
Susan J Kim1, Kaelyn C Cummins1, Allan Tsung1
1Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA.
Cancers
|May 25, 2024
概括
免疫疗法越来越多地用于肝细胞癌 (HCC),特别是在晚期. 本综述探讨了其在手术可控的HCC中不断变化的作用,包括新辅助和辅助治疗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 手术瘤学手术瘤学
- 医学瘤学 医学瘤学
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 虽然手术是早期HCC的标准,但许多患者患有晚期疾病或复发,需要全身疗法.
- 免疫疗法已成为中期和晚期HCC的关键治疗方法.
研究的目的:
- 审查当前关于免疫疗法的证据,对可接受外科治疗的HCC进行治疗.
- 讨论免疫治疗在HCC的新辅助和辅助环境中的影响.
- 探索系统疗法在潜在可治愈的HCC中不断变化的作用.
主要方法:
- 临床试验和研究的文献综述.
- 在接受手术或有资格接受手术的HCC患者中分析免疫疗法的疗效.
- 对新辅助剂和辅助剂免疫治疗方案的数据的检查.
主要成果:
- 阿特佐利祖马布/贝瓦西祖马布已被确立为高级HCC的第一线治疗方法.
- 免疫治疗在早期或手术切除的HCC中的作用仍在发展.
- 有证据表明,免疫疗法在HCC的新辅助和辅助环境中有益.
结论:
- 免疫疗法正在扩展到超出先进的HCC,以潜在地改善手术治疗患者的结果.
- 需要进一步的研究来优化HCC的新辅助和辅助免疫疗法策略.
- 包括免疫疗法在内的全身疗法正成为HCC治疗多式疗法不可或缺的一部分.
更多相关视频
07:32Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
1.3K
11:08Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
735
相关概念视频
Tumor Immunotherapy
515
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
515
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Cancer Vaccines
355
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
355
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
