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Eric Ovruchesky¹, Elizabeth Pan¹, Melis Guer¹

¹Division of Urologic Oncology, Department of Oncology, Moores Cancer Center, University of California San Diego, San Diego, CA 92037, USA.

|May 25, 2024

概括

在细胞癌 (RCC) 中高FOLH1表达与血管生成和更长的卡博桑提尼布治疗持续时间相关. 这一发现对于针对RCC患者的PSMA向疗法具有重要意义.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

前列腺特异性膜抗原 (PSMA) 向剂正在出现用于诊断和治疗应用.
了解细胞癌 (RCC) 中FOLH1 (编码PSMA的基因) 的表达模式对于利用这些药物至关重要.

研究的目的:

为了研究FOLH1在RCC中的表达模式.
确定FOLH1表达对RCC患者结局的影响.

主要方法:

这是一项对1,724名RCC患者的综合多机构分析.
进行了DNA和RNA下一代测序.
根据每百万RNA转录 (TPM),FOLH1表达被分类为高 (≥75百分位) 或低 (<25百分位).

主要成果:

与非清晰细胞RCC相比,清晰细胞RCC (ccRCC) 的FOLH1表达显著更高 (71%与19.0 TPM相比,p < 0.001).
FOLH1表达与血管性基因表达相关 (斯皮尔曼=0.76,p<0.001) 和内皮细胞丰度.
患有FOLH1高ccRCC的患者表现出卡博赞提尼比治疗的持续时间更长 (9.7个月与4.6个月,HR0.57,p <0.05).

结论:

根据RCC组织学和瘤部位,FOLH1表达模式有所不同.
在ccRCC中,FOLH1表达与血管生成,整体存活率 (OS) 和延长卡博桑提尼布治疗反应有关.

关键词:

在FOLH1中,FOLH1是FOLH1的代名词.诊断诊断诊断诊断诊断分子造型分析 (MOP) 是一种分子造型分析.细胞癌瘤是细胞癌.治疗药物治疗药物

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