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在前列腺癌的根源性前列腺切除术后,组织学上开放的肌肉反应和进展的风险

Mutlay Sayan¹, Yetkin Tuac², Samet Kucukcolak³

¹Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

|May 25, 2024

概括

在接受手术的前列腺癌患者中,肌体反应与更糟糕的结果有关. 这一发现表明辅助疗法可能有利于HOST反应的患者,这需要进一步的临床试验.

科学领域:

在瘤学瘤学.
病理学病理学病理学
癌症研究癌症研究

背景情况:

前列腺癌表现出可变的临床轨迹.
目前前前列腺癌的预后因素有局限性.
组织学上明显的树皮反应 (HOST-响应) 是一个潜在的预后标志物.

研究的目的:

研究HOST反应对前列腺癌患者临床结果的影响.
为了确定HOST-响应是否预测激进前列腺切除术后的无进展生存.

主要方法:

癌症基因组图谱 (TCGA) 前列腺癌队列的回顾性分析.
激进前列腺切除术病理学幻灯片的评估用于HOST响应.
无进展生存期 (PFS) 的多变量竞争风险回归分析.

主要成果:

在348名患者中,47.70%的患者表现出HOST反应.
HOST反应与更短的PFS显著相关 (SHDR,2.10;p=0.004).
经过对已知的预后因素进行调整后,研究结果仍然具有意义.

结论:

HOST反应是前列腺切除术后PFS显著的负预后因素.
具有HOST反应的患者可能会从辅助疗法中受益.
需要未来的随机试验来证实这些发现.

关键词:

东道主响应响应.辅助疗法是一种辅助疗法.没有进展的生存率.前列腺癌是前列腺癌.进行激进的前列腺切除术.

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