整合成像和循环瘤DNA特征来预测患者的结果
Mark Jesus M Magbanua1, Wen Li2, Laura J van 't Veer1
1Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94115, USA.
Cancers
|May 25, 2024
概括
整合成像和循环瘤DNA生物标志物显示出预测癌症治疗反应和复发风险的前景. 需要对更大的队列进行进一步的研究,以开发准确的,可概括的预测模型.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 翻译医学是一种翻译医学.
背景情况:
- 准确的瘤反应评估和复发风险预测是临床的关键需求.
- 目前的方法包括成像 (PET/CT,MRI) 和微创液体活检 (循环瘤DNA).
- 结合成像和循环瘤DNA (ctDNA) 生物标志物,可以提高患者的预测结果.
研究的目的:
- 审查结合定量成像和ctDNA生物标志物的原始研究,以开发预测模型.
- 评估综合成像-ctDNA预测模型的可行性和当前状态.
- 确定这个新兴领域未来研究的需求.
主要方法:
- 系统地在文献中搜索整合定量成像和ctDNA生物标记物的研究.
- 对开发预后或反应预测模型的研究进行分析.
- 专注于回归和机器学习方法用于模型构建.
主要成果:
- 七项研究开发了生存结果的预后模型 (无复发,无进展,整体存活).
- 三项研究专注于使用终点,如瘤体积和响应率来预测治疗反应.
- 该领域还处于芽阶段,研究有限,队列规模不大.
结论:
- 将成像和ctDNA生物标记物结合起来,可用于开发多变量预测模型.
- 目前的模型有希望,但需要在更大,更多样化的患者群体中进行验证.
- 未来的研究应该专注于更大的研究,以提高模型的准确性和通用性.
相关概念视频
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02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...