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Updated: Jun 25, 2025

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
10:16

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Published on: January 6, 2017

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在SCLC细胞系中对NRF2和NOTCH通路的KEAP1沉默的影响

Federico Pio Fabrizio1,2,3, Angelo Sparaneo1, Giusy Gorgoglione1

  • 1Laboratory of Oncology, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.

Cancers
|May 25, 2024
PubMed
概括

在小细胞肺癌 (SCLC) 中功能障碍的KEAP1/NRF2信号促进瘤生长和化学抵抗. 对KEAP1的表观遗传沉默会破坏NRF2和NOTCH通路,影响癌细胞存活率和药物反应.

关键词:
在DLL-3中,它是DLL-3.HES1 HES1 的时间这就是KEAP1的意义.没有任何东西.这就是NRF2的NRF2.在SCLC中,SCLC是最重要的.

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