乳球菌 (Lactococcus lactis) 的亚种. C60 通过修改代谢偏好以增强抗瘤免疫力来提高巨细胞功能
Suguru Saito1,2, Duo-Yao Cao2, Toshio Maekawa3,4
1Department of Infection and Immunity, Division of Virology, Faculty of Medicine, Jichi Medical University, Shimotsuke, Tochigi 3290431, Japan.
Cancers
|May 25, 2024
概括
乳球菌乳糖C60是一种益生菌,通过促进巨细胞代谢和ATP生产来增强抗瘤免疫力. 这促进了CD8+T细胞的反应,抑制了小鼠的黑色素瘤生长.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 代谢工程是代谢工程.
背景情况:
- 益生菌乳酸细菌 (LAB) 调节免疫反应.
- 乳球菌乳酸菌亚种. 克雷莫里斯C60 (C60) 显示了免疫增强的潜力.
研究的目的:
- 为了研究C60在小鼠黑色素瘤模型中的抗瘤作用.
- 阐明C60增强巨细胞功能和抗瘤免疫力的机制.
主要方法:
- 在患有黑色素瘤的小鼠体内给予C60.
- 对巨细胞表型 (M1/M2) 和抗原呈现能力的分析.
- 内巨细胞的代谢分析,重点是糖解与脂肪酸氧化 (FAO).
- 对托尔类受体 (TLR) 信号通路的研究.
主要成果:
- C60的使用显著降低了瘤体积.
- C60上调抗瘤 (M1) 巨细胞功能和抗原呈现,增加瘤特异性CD8+ T细胞.
- C60诱导了转向糖解的转变,增加了巨细胞中的ATP产量.
- 细菌细胞壁的成分可能会激活外围巨细胞中的TLRs,解释系统性影响.
结论:
- C60通过对糖溶解进行代谢重编程来增强巨细胞的抗瘤免疫力.
- 这种代谢转变增强了ATP的产生和抗瘤反应.
- 通过C60组件的TLR介导的信号传递有助于系统性免疫调节.
更多相关视频
11:48Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
Published on: May 31, 2018
11.4K
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
7.5K
相关概念视频
01:31Defense Against Bacterial Pathogens
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...