血清标记物和子宫内膜癌之间的临床相关性
Alina-Gabriela Marin1,2, Alexandru George Filipescu1,2, Răzvan Cosmin Petca1,3
1"Carol Davila" Faculty of Medicine, Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Cancers
|May 25, 2024
概括
淋巴细胞计数和炎症标志物等血液标志物显示子宫内膜癌和子宫内膜癌之间存在显著差异. 这些负担得起的生物标志物可能有助于诊断和预后.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 子宫内膜癌与血液细胞数量变化和炎症标志物有关.
- 中性细胞与淋巴细胞的比率 (NLr),血小板与淋巴细胞的比率 (PLr) 和单细胞与淋巴细胞的比率 (MLr) 是恶性瘤的潜在预后指标.
研究的目的:
- 在患有良性 (子宫内膜增生) 与恶性 (子宫内膜癌) 子宫内膜瘤的患者中比较各种血液标志物.
- 评估这些血清学参数的诊断和预后潜力.
主要方法:
- 对670名患者进行了回顾性研究 (192例子宫内膜癌,478例子宫内膜增生病).
- 术前全血细胞计指数,血小板参数和炎症标志物 (C反应蛋白,纤维素,NLr,PLr,MLr) 的比较.
主要成果:
- 红细胞或总白细胞计数没有显著差异.
- 子宫内膜癌组显示淋巴细胞数量减少,平均血小板数量增加,平均血小板体积增加.
- 与增生症组相比,子宫内膜癌组的C反应蛋白,纤维素,NLr,PLr和MLr显著更高.
结论:
- 在子宫内膜癌和子宫内膜癌之间存在多种血清生物标志物的统计学上显著差异.
- 这些发现支持这些负担得起的生物标志物的实用性,用于子宫内膜癌的诊断,预后和治疗反应.
- 已识别的生物标志物可以在全球的医疗保健系统中获得.
相关概念视频
01:24Disorders of the Female Reproductive System
354
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
354
01:30Serum Laboratory Studies, Stool Test, Breath Test
334
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
334