创新的固相提取策略,以改善在具有挑战性的生物样本中药物的先进染色学测定
Mohammadreza Mahdavijalal1, Carmine Petio2, Giovanni Staffilano3
1Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
Molecules (Basel, Switzerland)
|May 25, 2024
概括
固体吸附剂样品制备技术的最新进展,特别是分子印记聚合物 (MIPs),提高了生物样品中的药物分析. 这些智能吸附剂通过优化药物血水平来提高准确性和患者安全性.
科学领域:
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
背景情况:
- 精确的药物血水平对于患者的安全至关重要,尽管药物分析取得了重大进展.
- 传统的样本准备技术 (SPT) 在实现最佳准确性和效率方面面临着挑战.
研究的目的:
- 审查过去十年生物样品固体吸附剂基础的SPT的进展.
- 专注于分子印记聚合物 (MIP) 作为药物分析的"智能吸附剂".
- 探索先进的SPT与液态染色体质谱法 (LC-MS) 技术的整合.
主要方法:
- 使用固体吸附剂进行固体相提取 (SPE) 和固体相微提取 (SPME) 的审查.
- 详细检查分子印记聚合物 (MIP),包括对刺激有反应和无反应的类型.
- 分析了先进的SPT与各种液态染色体质谱 (LC-MS) 平台 (HPLC,UHPLC,MS/MS,HRMS) 和HPLC-UV/DAD的合.
主要成果:
- 智能吸附剂 (MIP) 提供针对刺激 (磁场,pH,温度,光) 的量身定制反应,以改善样品制备.
- 先进的SPT,特别是MIP,显著提高了与LC-MS相结合的现代药物分析的能力.
- 该评论讨论了这些先进技术的优点和缺点,以及它们与分析方法的结合.
结论:
- 先进的样本制备技术,特别是MIP,正在彻底改变生物样本中的药物分析.
- 这些方法通过精确控制药物的血水平来提高准确性,效率和患者安全.
- 未来的前景包括在临床和法医毒理学中进一步开发和应用智能吸附剂.
关键词:
人类生物流体生物流体质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量多阶段质谱测量多阶段质谱测量智能吸附剂是一种智能吸附剂.固体阶段提取的方法治疗药物监测 治疗药物监测更多相关视频
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