Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1.

BMC cancer·2022
Same author

Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation.

International journal of medical sciences·2022
Same author

Preoperative serum hepatitis B virus DNA was a risk factor for hepatocellular carcinoma recurrence after liver transplantation.

Annals of medicine·2022
Same author

Case Report: Cardiac Multiple Thrombus and Pulmonary Embolism Associated With Mycoplasma Pneumonia Infection in a Child.

Frontiers in pediatrics·2022
Same author

Dual antigen-targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia.

Blood·2022
Same author

Substrate-free fluorescence ratiometric detection of serum acetylcholinesterase activity with a self-assembled CsPbBr<sub>3</sub> perovskite nanocrystals/tetraphenylporphyrin tetrasulfonic acid nanocomposite.

Talanta·2022
Same journal

RETRACTED: Atta et al. Effect of Montmorillonite Nanogel Composite Fillers on the Protection Performance of Epoxy Coatings on Steel Pipelines. <i>Molecules</i> 2017, <i>22</i>, 905.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
查看所有相关文章

相关实验视频

Updated: Jun 25, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

13.8K

一种合成伊普塔科潘的实用方法.

Zhiwei Tang1, Shaojie Chu1, Xuesong Wu1

  • 1National Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai 201203, China.

Molecules (Basel, Switzerland)
|May 25, 2024
PubMed
概括
此摘要是机器生成的。

开发了一种新的合成途径Iptacopan,一个补充因子B抑制剂用于PNH治疗,使用生物催化剂用于关键中间体. 这种方法提高了效率,并为制药制造提供了基础.

关键词:
这就是Iptacopan.补充路径是补充路径.氨酸减少酶可以减少氨酸.

更多相关视频

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.2K
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
10:44

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Published on: April 19, 2019

10.8K

相关实验视频

Last Updated: Jun 25, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

13.8K
Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.2K
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
10:44

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Published on: April 19, 2019

10.8K

科学领域:

  • 制药化学 制药化学 制药化学
  • 有机合成 有机合成
  • 生物催化剂是一种生物催化剂.

背景情况:

  • 伊普塔科潘是第一个口服可用的小分子补充因子B抑制剂,最近被批准用于PNH治疗.
  • 对于伊普塔科潘及其中间体的现有合成细节是有限的,主要限于原始专利.
  • 需要为制药制造提供实用和可扩展的合成路径.

研究的目的:

  • 为Iptacopan开发一种实用和高效的合成途径.
  • 使用生物催化剂优化关键中间体的合成.
  • 为未来的Iptacopan制药制造奠定基础.

主要方法:

  • 通过渐进的改进,开发了一种实用的Iptacopan合成途径.
  • 采用生物合成和酶选 (随机和位点定向突变发生) 来获得高产量的缩酶 (M8) 用于中间合成.
  • 优化了中间体15的合成,从两步过程改为一步过程.

主要成果:

  • 在七步过程中成功合成了Iptacopan,总产量为29%.
  • 使用M8酶的生物催化方法,产生具有高光学纯度 (99% ee) 和产量的关键中间体.
  • 改善了中间体15的合成,降低了奇拉性全osterism的风险,并使扩大规模.

结论:

  • 已经建立了一个实用且高效的Iptacopan合成途径.
  • 生物催化提供了一种可行的方法,用于生产具有高纯度和产量的性中间体.
  • 开发的合成为Iptacopan的未来制药制造提供了坚实的基础.