肺功能,计算机断层扫描肺部异常和COVID-19后的小呼吸道疾病:3个,6个和9个月的随访
Krzysztof Kłos1, Dominika Jaskóła-Polkowska1, Katarzyna Plewka-Barcik1
1Department of Internal Medicine, Infectious Diseases and Allergology, Military Institute of Medicine-National Research Institute, Szaserow Str. 128, 04-141 Warsaw, Poland.
Journal of clinical medicine
|May 25, 2024
概括
由于肺部痕和炎症引起的气道狭窄,COVID-19幸存者可能会经历持续的呼吸道问题,这会影响长期的肺功能. 这些变化会影响气体交换和空气流,特别是在严重的情况下.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 冠状病毒疾病2019 (COVID-19) 可能导致严重的肺炎和长期呼吸道并发症.
- 并发症可能会加剧COVID-19的严重程度,并影响感染后的肺部异常.
研究的目的:
- 为了调查COVID-19后的长期结构性肺部异常.
- 评估这些异常对呼吸功能的影响,包括周围气道功能和气体转移.
主要方法:
- 176名住院COVID-19患者根据世卫组织的严重程度分为轻度/中度和重度/危急等级.
- 肺功能测试 (精神测量,胸膜造影) 和CT扫描是在住院后的3,6个月和9个月进行的.
主要成果:
- 严重/危急的COVID-19患者在住院后3个月显示肺体积 (FVC,FEV1,TLC) 和气体转移 (DLCO) 显著降低.
- 在6个月或9个月后,在两组中都没有观察到FVC或FEV1的显著改善.
- 在严重/危急的患者中,在螺旋计/斑管学参数,CT发现和气体转移之间发现了微弱的相关性;在轻度/中度患者中发现了显著的负相关性.
结论:
- 在COVID-19后持续的呼吸道症状可能源于纤维化肺瘤.
- 感染后的狭窄小气道变化,可能是由于正在进行的炎症而导致的,并且在CT上并不总是可见的,也可能有所贡献.
- 这些因素在急性感染后的很长一段时间内共同损害了肺功能和气体交换.
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