李氏硬化病的发生率和并发症:一项全国性的瑞典注册研究
Sandra Jerkovic Gulin1,2, Filippa Lundin3, Olle Eriksson4
1Department of Dermatology and Venereology, Ryhov County Hospital, Sjukhusgatan, 553 05 Jönköping, Sweden.
Journal of clinical medicine
|May 25, 2024
概括
状硬化症 (LS) 患者患上各种癌症的风险明显更高,包括部和阴茎癌以及前性疾病. 这凸显了对LS和自身免疫性疾病的联系进行勤奋的跟进和进一步研究的需要.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 从基于人口的登记册中,关于状硬化菌 (LS) 的发病率和并发病率的数据有限.
- 了解LS并发症对于患者管理和风险评估至关重要.
研究的目的:
- 为了确定瑞典LS的发病率.
- 调查LS与各种恶性瘤和自身免疫性疾病之间的关联.
主要方法:
- 一项回顾性开放队列研究利用了瑞典国家患者登记册.
- 包括154,424名LS患者和463,273名来自2001-2021年的匹配对照.
- 评估癌症和癌前疾病的发病率和几率比率.
主要成果:
- 每10万人/年中LS的发病率为80.9,女性的发病率更高.
- 在LS患者中,阴道癌 (OR=8.3),阴茎癌 (OR=8.9) 和阴道白血病 (OR=253.5) 的几率增加.
- 还观察到前列腺,丸,膀,乳腺癌和阴茎白血病的风险增加.
结论:
- LS与各种癌症和先发性疾病的风险增加有显著的关联.
- 有效的治疗和勤奋的随访对LS患者至关重要.
- 需要进一步的研究来了解LS-自身免疫性疾病的联系和癌症发展机制.
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