在患有结性脊柱炎的患者中增加肺栓塞风险 - - 来自大型数据库分析的结果
Omer Gendelman1,2, Neta Simon1,2, Niv Ben-Shabat1,2
1Internal Medicine B, Sheba Medical Center, Tel-Hashomer, Ramat Gan 52621, Israel.
Journal of clinical medicine
|May 25, 2024
概括
轴性脊椎骨关节病 (AS) 患者面临着显著更高的肺栓塞 (PE) 风险. 这项研究发现,AS患者患PE的风险增加了1.70倍,这表明炎症起着关键作用.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 轴性脊髓关节病 (AS) 是一种慢性炎症状况,影响轴性骨架.
- 肺栓塞 (PE) 是一种与自身免疫性疾病相关的严重疾病,但其在AS患者中的风险未得到充分研究.
研究的目的:
- 调查轴性脊髓关节病 (AS) 与肺栓塞 (PE) 风险之间的关联.
- 为了确定AS是否独立增加PE风险.
主要方法:
- 使用克拉利特医疗保健服务 (CHS) 数据库进行回顾性队列研究.
- 包括5825名AS患者和28356名匹配对照.
- 随访直到PE诊断,死亡或研究结束.
主要成果:
- 在诊断前,AS患者的PE患病率较高 (0.4%与0.2%,p <0.01).
- 在AS患者中,PE的发病率为每1万人年11.6,对照组为6.8.
- 在AS患者中,PE的调整后危险比为1.70 (p < 0.001),独立于年龄和性别.
结论:
- 轴性脊椎骨关节病与肺栓塞的风险增加显著相关.
- 这些发现表明,AS的潜在炎症可能会导致PE风险.
- 免疫抑制药物可能会提供保护,因此需要进一步研究治疗策略.
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