渐进的年龄可能会降低堆积细胞中的线粒体活动
Suwichaya Jitngamsujarit1, Lingling Salang1, Charupong Saengboonmee2
1Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Journal of clinical medicine
|May 25, 2024
概括
孕产妇年龄的提升会降低累积细胞 (CCs) 中的线粒体活动,但不会影响母细胞质量. 然而,男性年龄在不孕症治疗中可以预测高等级囊发育.
科学领域:
- 生殖生物学 生殖生物学
- 细胞生物学 细胞生物学
- 不孕症研究 不孕症研究
背景情况:
- 累积细胞 (CCs) 中的线粒体功能对于卵细胞质量和胚胎发育至关重要.
- 与年龄相关的线粒体活性下降可能会影响生育结果.
- 了解这些因素对于改善辅助生殖技术 (ART) 是必不可少的.
研究的目的:
- 为了比较年轻和老年妇女接受细胞内精子注射 (ICSI) 之间的CCs中的线粒体活性.
- 确定影响CCs线粒体活动的因素.
- 为了研究线粒体活动与胚胎细胞质量之间的关联.
主要方法:
- 对80名接受ICSI的不育妇女进行前性研究,分为年龄组 (≥38岁和<38岁).
- 使用MitoTracker和平均光强度 (MFI) 评估了CC中的线粒体活性.
- 进行了单变量和多变量回归分析,以确定影响因素和关联.
主要成果:
- 与年轻女性相比,38岁以上的女性在CC中显示MFI显著较低 (p=0.005).
- 孕产妇年龄 (≥38),总淋巴激素剂量和GnRHa触发受影响的MFI,在多变量分析中,孕产妇年龄仍然显著.
- 男人的年龄,但不是母亲的年龄或CC线粒体活动,与高质量的胚胎细胞质量有关.
结论:
- 母亲年龄的提升与CCs中线粒体活性降低有关.
- 在CC中线粒体活动似乎不会影响芽细胞质量.
- 男人的年龄可以作为在ART中实现高等级囊的预测指标.
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