右与左结肠直肠癌的临床病理学差异,按性别分类
Hannah Ra1, Soyeon Jeong2,3, Hannah Lee1
1Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Republic of Korea.
Journal of clinical medicine
|May 25, 2024
概括
结肠直肠癌 (CRC) 根据瘤的位置和性别表现出不同的特征. 右侧CRC与男性和女性的较高贫血和不分化癌症有关,突出显示需要针对性别的个性化治疗.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 医学研究 医学研究
背景情况:
- 结肠直肠癌 (CRC) 研究经常忽视性别差异,尽管男性和女性之间存在生理差异.
- 以前对CRC临床病理特征的研究主要集中在瘤位置上,忽视了性别的影响.
研究的目的:
- 调查右侧结直肠癌 (RCC) 和左侧结直肠癌 (LCC) 之间的性别特异性临床病理学差异.
- 确定瘤位置和性别是否相互作用影响CRC特征.
主要方法:
- 对1492名韩国患者的分析,他们之前没有结肠外科手术史 (2005年7月至2015年6月).
- 根据瘤位置 (RCC与LCC) 和性别对患者进行分类.
- 单变量和多变量分析以比较组之间的临床特征.
主要成果:
- 左侧CRC (LCC) 比右侧CRC (RCC) (25.1%) 更常见 (74.9%).
- 与LCC相比,RCC在两种性别中显示出较高的贫血和不分化的癌症率.
- 65岁以上的年龄和异常的白细胞计数仅在女性中是RCC和LCC之间的显著差异.
结论:
- 结肠直肠癌的临床病理特征受到瘤位置和患者性别的影响.
- 在制定个性化的CRC治疗策略时,性别应该是基本考虑因素.
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