患者的微血管密度分析不活跃的系统性红斑狼-一个两年的随访光学一致性断层扫描血管学研究研究
Martin Dominik Leclaire1, Eliane Luisa Esser1, Sebastian Dierse1
1Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany.
Journal of clinical medicine
|May 25, 2024
概括
不活跃的系统性红斑狼 (SLE) 患者在两年内显示了视网膜微循环的减少. 这项研究发现,表面毛细血管和胆管毛细血管的血管密度下降,与氧化剂量无关.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 系统性红斑狼 (SLE) 是一种自身免疫性疾病,具有潜在的系统性影响.
- 视网膜微循环可能会受到系统性疾病的影响.
- 光学连贯断层扫描血管学 (OCT-A) 允许详细可视化视网膜血管结构.
研究的目的:
- 评估不活跃的SLE对视网膜微循环的长期影响.
- 为了评估两年内血管密度 (VD) 和骨无血管区 (FAZ) 的变化.
- 研究HCQ剂量与视网膜微循环变化之间的关系.
主要方法:
- 在24名不活跃的SLE患者中进行氧化 (HCQ) 治疗的长度研究.
- 在表面 (SCP) 和深层 (DCP) 毛细管中分析VD和FAZ的OCT-A成像,以及choriocapillaris (CC).
- 在基线 (t0) 和2年随访 (t1) 时的OCT-A参数的比较.
主要成果:
- 面对SCP和CC的VD从t0到t1显著减少 (分别为p=0.001和p=0.013).
- 在DCP的VD,FAZ区域或中枢视网膜厚度 (CRT) 中没有观察到显著的变化.
- 在累积的HCQ剂量增加和SCPVD变化之间没有发现相关性.
结论:
- 不活跃的SLE与视网膜微循环的逐渐下降有关,特别影响SCP和CC.
- 观察到的微循环变化可能与疾病有关,而不是HCQ治疗的副作用.
- 这些发现强调了监测SLE患者视网膜健康的重要性.
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