在肺移植中治疗慢性肺异质移植功能障碍的Everolimus治疗
David Iturbe-Fernández1, Alicia de Pablo Gafas2, Víctor Manuel Mora Cuesta1
1Lung Transplant Unit, Pulmonary Medicine Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
Life (Basel, Switzerland)
|May 25, 2024
概括
埃弗罗利莫斯治疗可能会减缓肺部功能下降的肺部移植接受者慢性肺部异位移植功能障碍. 然而,大量患者因不良事件而停止服用药物.
科学领域:
- 肺部病理学 肺部病理学
- 移植医学 移植医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性肺异位移植功能障碍 (CLAD) 是肺移植接受者长期发病和死亡的主要原因.
- 作为一种mTOR抑制剂的Everolimus已经显示出在治疗各种移植后并发症方面的潜力.
研究的目的:
- 评估Everolimus在被诊断患有CLAD的肺移植患者改善肺功能方面的疗效.
- 评估everolimus在这个患者群体中的安全性和耐受性.
主要方法:
- 在2008年10月至2016年10月期间,对肺移植 (LT) 患者进行回顾性分析,这些患者接受了Everolimus治疗的CLAD.
- 在开始服用everolimus之前和之后,评估一秒钟内强迫呼气体积 (FEV1) 的变化.
- 监测膜过率 (GFR) 以评估功能.
主要成果:
- 治疗Everolimus与FEV1下降率在开始后12个月内显著降低相关 (p <0.05).
- 在整个研究期间,淋巴膜过率保持稳定,这表明对功能没有显著影响.
- 很大一部分患者 (38.6%) 停止服用埃弗罗利莫斯,平均停药时间为14.1个月.
结论:
- 埃弗罗利斯在患有CLAD的肺移植接受者中减缓FEV1下降具有有益作用.
- 尽管有潜在的益处,但药物戒断率高,需要对患者进行仔细的选择和对不良事件的监测.
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