素和菌体减少活料和鱼幼虫中的菌体数量
Jaime Romero1, Sergueia Blas-Chumacero1, Victoria Urzúa1
1Laboratorio de Biotecnología de Alimentos, Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, El Líbano 5524, Santiago 7830489, Chile.
Microorganisms
|May 25, 2024
概括
生物制剂,如菌体CH20和内素LysVPp1,有效地降低了水产养殖中的Vibrio细菌负载. 这种非抗生素方法提供了一种可持续的解决方案,用于对抗鱼类和活体料中的Vibrio感染.
科学领域:
- 水生微生物学 水生微生物学
- 抗微生物耐药性 抗微生物耐药性
- 可持续的水产养殖
背景情况:
- 活菌物种是常见的海洋细菌和重要的人类肠道病原体.
- 使用抗菌素的水产养殖实践有助于抗菌素耐药性 (AMR).
- 病毒感染导致水产养殖业的重大损失.
研究的目的:
- 评估菌体CH20和内素LysVPp1对于减少Vibrio负载的作用.
- 评估LysVPp1对致病性Vibrio菌株的催化活性.
- 展示一种非抗生素策略,用于控制水产养殖中的Vibrio.
主要方法:
- 通过减少对Vibrio菌株的吸收能力来评估LysVPp1的催化活性.
- 确定菌体CH20宿主范围.
- 进行了生物测试,以评估CH20和LysVPp1在虫和鱼幼虫中的有效性.
主要成果:
- 恩多利辛LysVPp1显示出针对Vibrio alginolyticus,Vibrio parahaemolyticus和Vibrio splendidus的显著的性活性.
- 菌体CH20表明宿主范围有限,仅针对Vibrio alginolyticus GV09.09.
- 在活料和鱼幼虫中使用菌体和endolysin减少致病性Vibrio负载.
结论:
- 生物制剂LysVPp1和菌体CH20可以有效地降低Vibrio细菌负载.
- 对于可持续的水产养殖来说,使用Lytic Phage和Endolysin的非抗生素方法是可行的.
- 该战略通过减轻AMR和Vibrio感染,支持一个健康的观点.
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