显著的胃肠道和生殖微生物模式在女性的全生物不孕不育
Ana T Marcos1,2,3,4, Maria J Rus5, Victoria Areal-Quecuty5
1Unidad de Genética, INEBIR (Instituto para el Estudio de la Biología de la Reproducción Humana), 41001 Sevilla, Spain.
Microorganisms
|May 25, 2024
概括
不孕症会影响女性生殖系统和肠道微生物群. 子宫内膜异位症病例显示出独特的肠道相关微生物,这表明一种独特的肠道相关微生物.
科学领域:
- 微生物组研究的研究.
- 生殖健康 生殖健康
- 人类全生物研究研究.
背景情况:
- 人体与其微生物群共生,形成了一个全生物体.
- 不孕症与女性生殖道 (FRT) 微生物组的变化有关.
- 微生物组的干扰可能会影响身体的遥远部位,如胃肠道 (GIT).
研究的目的:
- 调查不育患者FRT和GIT中的特定身体部位的微生物模式.
- 识别与子宫内膜异位症和其他不孕症相关的独特微生物特征.
- 在不孕症的背景下探索"女性全生物体"的概念.
主要方法:
- 从子宫内膜,子宫内膜液,阴道,口腔和样中分析16S rRNA基因序列.
- 包括21名患有子宫内膜异位症和其他不孕症相关疾病的患者.
- 估计微生物多样性指标和确定特定地点的微生物模式.
主要成果:
- 在FRT和GIT之间观察到不同的体位特定的微生物模式.
- 乳酸菌是两组子宫内膜和阴道样本之间共享的Amplicon序列变异 (ASV).
- 海莫菲勒斯在子宫内膜异位症病例中是一个特定的GIT共享分类,使其与其他疾病区别开来.
结论:
- 不孕症明显影响FRT和GIT的微生物组.
- 子宫内膜异位症在GIT微生物群中表现出独特的微生物特征.
- 在"雌性全生物体"中恢复微生物平衡可能为提高生育能力提供治疗途径.
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