面部皮肤微生物组合和功能转变与衰老
Allison Garlet1, Valerie Andre-Frei2, Nicolas Del Bene1
1BASF Corporation, 540 White Plains Road, Tarrytown, NY 10591, USA.
Microorganisms
|May 25, 2024
概括
老化显著改变了面部皮肤的微生物组. 老年人表现出更多的多样性,细菌种群的变化,如减少Cutibacterium acnes和增加Corynebacterium kroppenstedtii.
科学领域:
- 微生物学 微生物学
- 皮肤病学 皮肤病学
- 衰老研究研究 衰老研究
背景情况:
- 衰老过程对人类皮肤微生物群产生重大影响,但对其全面的理解仍然有限.
- 皮肤微生物组的组成和功能对于保持皮肤健康和屏障完整性至关重要.
- 皮肤微生物组的与年龄相关的变化可能会影响皮肤的老化和对疾病的敏感性.
研究的目的:
- 调查面部皮肤微生物组组成和功能的与年龄相关的变化.
- 为了比较年轻 (18-35岁) 和年长 (≥55岁) 的女性志愿者之间的皮肤微生物群.
- 识别与皮肤衰老相关的特定细菌种群和功能基因通路.
主要方法:
- 来自100名健康的高加索女性志愿者的面部皮肤拭子的全基因组测序.
- 志愿者被分为两个年龄组 (18-35岁和≥55岁) 和根据纹级别进行分类.
- 使用分类学和非度数多维缩放分析微生物组组成;通过基因本体学 (GO) 术语进行功能分析.
主要成果:
- 皮肤微生物组在老年人群 (≥55岁) 中显著多样化.
- 老年人显示Actinobacteria (特别是Cutibacterium acnes) 的减少和Corynebacterium身体stedtii的增加.
- 年轻的成年人 (18-35岁) 的Cutibacterium acnes和Lactobacillus (特别是Lactobacillus crispatus) 的比例较高,在代谢和保护性途径中基因表达增强.
结论:
- 老龄化导致面部皮肤微生物群多样性和组成的明显变化,细菌种群的特定变化.
- 较年轻的皮肤微生物群的特点是Cutibacterium acnes和Lactobacillus的数量较高,以及增强的保护功能.
- 了解这些与年龄相关的微生物组变化为探索它们在皮肤衰老和抗衰老策略中的作用提供了基础.
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