对新确诊结核病患者和正常人群中维生素D水平的比较研究
Vasanth Kumar Mamadapur1, Shreesha Nagaraju1, Mukhyaprana M Prabhu1
1Department of General Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Medicina (Kaunas, Lithuania)
|May 25, 2024
概括
与健康人相比,结核病患者中维生素D缺乏更为常见. 这项研究强调了低维生素D水平与结核病之间的联系,表明维生素D在结核病管理中的潜在作用.
科学领域:
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 由Mycobacterium tuberculosis引起的结核病 (TB) 给全球健康带来了重大挑战.
- 耐药性和长时间的治疗时间使结核病管理复杂化.
- 以前的研究表明,维生素D在结核病发病和治疗中的作用,但体内结果不一致.
研究的目的:
- 调查新诊断的肺结核和肺外结核病例中的维生素D水平.
- 为了比较结核病患者和健康的对照人群之间的维生素D水平.
- 为了确定维生素D状态和结核病之间的关联.
主要方法:
- 一项前性病例控制研究,涉及116名参与者 (58例结核病例,58例对照).
- 在所有参与者身上测量了血清维生素D水平.
- 使用SPSS软件 (22.0版本) 进行统计分析.
主要成果:
- 在68.96%的结核病患者中观察到维生素D缺乏,对照组为51.72%.
- 与对照组 (19.08 ng/mL) 相比,结核病组的血清维生素D水平中位数较低 (14.35 ng/mL).
- 在结核病和非结核病人群之间发现了维生素D水平的统计学上显著差异 (p=0.029).
结论:
- 在结核病患者中,维生素D 缺乏明显更为普遍.
- 这些发现支持维生素D水平较低与结核病存在之间的关联.
- 进一步的研究可能会探索维生素D补充剂作为结核病的辅助疗法.
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