认知障碍老年人抑郁症状的网络结构
Jeehyung Pyo1, Hyukjun Lee2, Jakyung Lee2
1Samsung Medical Center, Department of Psychiatry, School of Medicine, Sungkyunkwan University, Seoul 06351, Republic of Korea.
Medicina (Kaunas, Lithuania)
|May 25, 2024
概括
在阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 中分析了抑郁症症状. 虽然核心症状有所不同 ("无价值"在AD中",空虚"在MCI中),但抑郁症的整体网络结构在各组之间仍然相似.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 老年学是一门学科.
背景情况:
- 患有阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的患者经常出现抑郁症状.
- 老年抑郁量表 (GDS) 是常用的,但这些患者群体的核心抑郁症状及其相互联系需要进一步探索.
研究的目的:
- 在患有AD和MCI的个体中识别核心抑郁症状.
- 研究认知障碍患者抑郁症状的网络结构,比较AD和MCI组.
主要方法:
- 在使用GDS的5354名患者 (1889名患有AD,3464名患有MCI) 的数据上利用探索性图形分析 (EGA).
- 评估症状的中心性 (强度,间距,接近) 并进行网络比较测试以分析AD和MCI组之间的差异.
主要成果:
- "无价值感"成为阿尔茨海默氏症组中最主要的抑郁症状.
- "空虚"被确定为MCI组中最主要的症状.
- 在AD和MCI组之间抑郁症状的整体网络结构中没有发现统计学上显著的差异.
结论:
- 这些发现增强了对认知障碍中抑郁症状表现的理解.
- 结果可以指导针对性干预的核心抑郁症状的识别和优先考虑.
- 对这些核心症状的量身定制干预措施的进一步研究可能有助于减轻认知衰退的进展.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48
Depressive Disorders: Etiology
68
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
68
Depressive Disorders: MDD and Dysthymia
100
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
100
Depression: Overview
238
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
238
Cognitive Development During Adulthood
93
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
93
Alzheimer's Disease: Overview
465
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
465


