住院COVID-19患者的主要出血事件:回顾性观察性研究
Andrea Poloni1,2, Giacomo Casalini2, Giacomo Pozza1,2
1Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20122 Milan, Italy.
Medicina (Kaunas, Lithuania)
|May 25, 2024
概括
在住院COVID-19患者中,主要出血事件发生在0.98%的患者中,老年是显著的风险因素. 严格监测对于接受抗凝治疗的老年COVID-19患者至关重要.
科学领域:
- 内部医学 内部医学
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 住院的COVID-19患者通常需要进行血栓预防或抗凝药.
- 在接受抗凝剂治疗的患者中,严重出血是一个重大问题.
研究的目的:
- 为了估计住院COVID-19患者主要出血事件的患病率.
- 为了确定与该人群中主要出血事件相关的因素.
主要方法:
- 在意大利北部的一个参考中心对COVID-19患者 (≥18岁) 的回顾性观察研究 (2020-2022年2月).
- 患病率计算为主要出血发作,除以风险患者.
- 用于评估风险因素的单变量和多变量Cox模型.
主要成果:
- 总共包括2945名患者;29名 (0.98%) 患有重大出血事件 (患病率0.5%).
- 五次出血事件是致命的.
- 患有严重出血的患者年龄较大 (中位数为78岁对67岁),并且更经常接受抗聚合疗法 (44.8%对20.0%).
- 增加年龄独立地与更高的重大出血风险相关 (AHR为每年1.05).
结论:
- 住院COVID-19患者的主要出血事件的患病率相对较低,但显著.
- 高龄是该队列中严重出血的关键独立风险因素.
- 建议对住院的老年COVID-19患者进行密切监测,以减轻出血风险.
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