骨质素:高血压患者周围动脉硬的潜在标记物
Yung-Hsuan Wang1, Chien-Hao Hsiao2, Ji-Hung Wang2,3
1Division of Chest Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan.
Medicina (Kaunas, Lithuania)
|May 25, 2024
概括
较高的血清骨质卡尔辛 (OC) 水平和年龄较大与高血压患者的外周动脉硬度 (PAS) 的增加有关. 这一发现凸显了OC作为这个人群中血管健康的潜在生物标志物.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 内分泌学 在内分泌学.
背景情况:
- 腕脉冲波速度 (baPWV) 是心血管风险的一个关键指标.
- 骨质素 (OC) 涉及到血管功能.
- 周围动脉硬 (PAS) 是心血管事件的重要预测因素.
研究的目的:
- 在高血压患者中研究血清骨质卡尔辛 (OC) 水平与外周动脉硬度 (PAS) 之间的关联.
- 确定OC是否是该队列中PAS的独立预测因素.
主要方法:
- 在120名高血压参与者中,使用ELISA测量了血清总OC水平.
- 通过腕脉冲波速度 (baPWV) 评估了外围动脉硬性 (PAS).
- PAS被定义为baPWV> 18.0 m/s. 这就是PAS的定义.
主要成果:
- 患有PAS的患者年龄较大,糖尿病,静脉血压,禁食葡萄糖,BUN,肌素,CRP和OC水平较高.
- 多变量逻辑回归确定了老年和较高的血清OC水平作为与PAS相关的独立因素.
- 而PAS组的估计膜过率显著降低.
结论:
- 血清骨质卡尔水平与高血压患者的外围动脉硬性有关.
- 高龄也独立地与该患者群体的PAS增加有关.
- OC可以作为一个有价值的生物标志物来评估高血压的血管硬.
相关概念视频
Assessment of blood pressure in brachial artery(one-step method)
584
This procedural guide systematically measures blood pressure using an oscillometric digital sphygmomanometer, emphasizing accuracy, patient safety, and comfort.
Prepare for the Procedure:
Prepare for the Procedure:
584
Assessment of blood pressure in brachial artery(two-step method)
693
Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
693
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
77
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
77
Sites for measruring blood pressure
1.7K
Blood pressure measurement is a fundamental clinical procedure, providing crucial data for assessing cardiovascular health. Among the various sites for this measurement, the brachial and popliteal arteries are predominantly utilized due to their accessibility and the reliability of their readings. This lesson delves into the anatomical significance, methodology, and considerations of measuring blood pressure at these locations.
The Brachial Artery: Primary Site for Blood Pressure Measurement
The Brachial Artery: Primary Site for Blood Pressure Measurement
1.7K
Equipments Used To Measure Blood Pressure
962
Direct Method
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
962


