乳腺癌中PD-L1和PD-L2蛋白的不同细胞表达模式
Julie M Jorns1, Yunguang Sun1, Sailaja Kamaraju2
1Department of Pathology, Froedtert and Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Journal of personalized medicine
|May 25, 2024
概括
编程死亡配体1 (PD-L1) 和PD-L2的表达在乳腺癌 (BC) 细胞和免疫细胞中不同. PD-L2可以补充PD-L1测试,用于选择患者接受抗PD-1免疫疗法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 编程死亡配体1 (PD-L1) 免疫组织化学 (IHC) 是预测乳腺癌 (BC) 对抗PD-1免疫疗法的反应的标准.
- 相关的配体PD-L2研究较少,但可以提供补充的预测价值.
研究的目的:
- 研究乳腺癌中PD-L1和PD-L2的独特表达模式.
- 评估PD-L2作为PD-L1的潜在补充生物标志物,用于预测ER+乳腺癌中抗PD-1治疗反应.
主要方法:
- 在32个乳腺癌样本中使用免疫组织化学对PD-L1和PD-L2表达的前性分析.
- 在癌细胞与免疫细胞中对PD-L1和PD-L2阳性的比较.
- 对PD-L1和PD-L2表达水平的相关性分析.
- 在雌激素受体阳性 (ER+) 瘤中评估PD-L1和PD-L2阳性.
主要成果:
- 免疫细胞中的PD-L1阳性显著高于癌细胞 (中位数为5.0%),而不是癌细胞 (中位数为0.0%).
- 癌细胞中PD-L2阳性显著高于免疫细胞 (中位数为30%) (中位数为5.0%).
- 在癌症或免疫细胞中,PD-L1和PD-L2表达水平没有相关性.
- 在ER+瘤 (n=23) 中,73.9%为PD-L2阳性,而40.9%为PD-L1阳性 (切割点≥1%).
结论:
- 乳腺癌中PD-L1和PD-L2的不同表达表明了不同的调节机制.
- PD-L2 IHC可以作为PD-L1的宝贵补充生物标志物.
- 结合PD-L1和PD-L2评估可以改善患者选择抗PD-1疗法,特别是在侵袭性ER+乳腺癌中.
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