在重症COVID-19-A回顾性研究中评估医院死亡风险的炎症生物标志物
Erika Bimbo-Szuhai1,2, Mihai Octavian Botea2,3, Dana Diana Romanescu2,4
1Department of Morphological Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Journal of personalized medicine
|May 25, 2024
概括
炎症标志物如C反应蛋白 (CRP),公素 (PCT) 和费里丁,以及高颗粒细胞/淋巴细胞 (G/L) 比率,预测严重的COVID-19患者的死亡率. 患有这些高标志物的老年肥胖患者面临更高的住院死亡风险.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 生物标志物和诊断方法
背景情况:
- 升高的白细胞 (WBC) 计数与COVID-19的严重程度相关,但缺乏对死亡率的预测能力.
- 识别早期预后指标对于在重症监护室 (ICU) 管理严重的COVID-19患者至关重要.
研究的目的:
- 为了研究炎症标志物对ICU住院COVID-19患者的疾病严重程度和死亡率的预后效用.
- 确定特定的生物标志物,可以快速分层高风险患者.
主要方法:
- 这是一项对209名在ICU中的COVID-19患者的回顾性观察性研究.
- 在第10和第14天评估C-反应蛋白 (CRP),前素 (PCT),粒细胞/淋巴细胞 (G/L) 比率,费里丁,年龄和肥胖.
- 分析了这些标志物对死亡率和疾病严重程度的预测值.
主要成果:
- 预测死亡率和严重程度的统计学显著差异观察到G/L比率 (p < 0.0001),PCT (p < 0.0002),CRP (p < 0.0001),费里丁 (p < 0.0001),年龄 (p < 0.0001) 和肥胖 (p < 0.0001).
- 一个G/L比率>20,升高的CRP,PCT和费里是显著的预测因素.
结论:
- 在接受ICU治疗的老年肥胖COVID-19患者中,高G/L比率,CRP,PCT和费里水平是住院死亡的重要风险因素.
- 这些炎症标志物可以帮助重症COVID-19病例的早期风险分层.
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