组织学疾病持续超过粘膜愈合,并可以预测性结肠炎的重新激活
Lucrezia Laterza1, Anna Chiara Piscaglia2, Stefano Bibbò3
1Centro per le Malattie dell'Apparato Digerente (CEMAD), Digestive Disease Center, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
即使粘膜愈合,性结肠炎患者持续组织学活动,特别是基底血细胞和表面不规则,面临更高的疾病复发风险.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 组织病理学 组织病理学
背景情况:
- 粘膜愈合 (MH) 是性结肠炎 (UC) 的首要治疗目标.
- 尽管获得了MH,但UC患者的一个子集经历了疾病的重新激活.
- 除了内镜愈合之外,持续的组织学活动 (HA) 可能会预测复发.
研究的目的:
- 确定UC患者MH中HA的患病率.
- 为了确定与临床复发相关的特定组织病变,在实现MH后.
主要方法:
- 追溯招募100名患有MH的UC患者 (梅奥内镜子评分0-1).
- 对UC相关病变的组织活检报告的审查.
- 在结肠镜检查后12个月内评估临床复发率.
主要成果:
- 两名患者没有组织病变;98人有一定程度的HA.
- 单变异性分析将较高的损伤数量,基底血细胞瘤,膜自身乙酸蛋白和表面不规则性与复发风险联系起来.
- 多变量分析证实基底血细胞 (OR 2.98) 和表面不规则 (OR 4.50) 是复发的显著预测因素.
结论:
- 组织学活性存在于UC患者中很大一部分的UC患者实现了粘膜愈合.
- 基底血细胞和表面不规则性是UCM患者复发风险增加的关键组织学指标.
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