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相关实验视频

Updated: Jun 25, 2025

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

关于微流体细胞中流场分布的研究,用于表面等离子体共振阵列检测.

Wanwan Chen¹, Jing Li², Peng Wang¹

¹Department of Precision Instrument, Tsinghua University, Beijing 100084, China.

Materials (Basel, Switzerland)

|May 25, 2024

概括

优化微流体电池设计,以135°的接触角度,最大限度地减少了对均流场的质量转移效应. 这提高了表面等离子体共振 (SPR) 阵列检测和高通量分析的准确性.

关键词:

在 SPR 阵列检测中使用 SPR 阵列检测.有限元素模拟的模拟器.流场流场流场流场流场微流体细胞是微流体细胞.

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Published on: August 27, 2013

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Last Updated: Jun 25, 2025

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Published on: May 5, 2016

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Published on: August 27, 2013

科学领域:

生物医学工程生物医学工程
分析化学分析化学
流体动力学流体动力学

背景情况:

精确的表面等离子体共振 (SPR) 阵列检测需要最小化质量转移效应,并确保微流体细胞中的均流场.
聚甲基 (PDMS) 是微流体设备的常见材料,但其表面特性可以影响流动力学.

研究的目的:

优化微流体细胞设计,以提高SPR阵列检测.
为了研究接触角度对微流体细胞内的流量均性的影响.
为了最大限度地减少质量转移效应,以提高检测准确度.

主要方法:

用有限元模拟来建模内部流动力学.
微粒子图像测速仪 (μPIV) 在聚甲基 (PDMS) 微流体细胞中测量了流速.
评估了各种不同接触角度的微流体电池设计.

主要成果:

135°的接触角度被认为是实现最均流量分布的最佳选择.
优化的设计显著提高了高通量阵列检测的能力.
实验结果通常与模拟预测保持一致,小的偏差归因于制造.

结论:

微流体电池设计的优化,特别是接触角度,对于统一的流量和准确的SPR检测至关重要.
135°的接触角度证明了高通量SPR阵列应用的卓越性能.
该研究证实了SPR系统中优化微流体细胞的可靠性和可重复性.