在后COVID综合征中肠道微生物组和细胞因子概况
Karakoz Mussabay1, Samat Kozhakhmetov2, Marat Dusmagambetov1
1Department of Microbiology and Virology Named after Sh.I.Sarbasova, Astana Medical University, Astana 010000, Kazakhstan.
Viruses
|May 25, 2024
概括
严重的COVID-19改变了肠道微生物组,创造了与长时间症状相关的炎症性环境. 这种肠道失调和相关的细胞因子变化为治疗COVID后疾病提供了潜在的点.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 肠道微生物组在感染后并发症中起作用.
- 严重的COVID-19可能导致长期的健康问题.
研究的目的:
- 为了研究肠道微生物组变化与COVID后综合征患者的细胞因子概况之间的联系.
- 了解与长期COVID相关的肠道微生物组的功能变化.
主要方法:
- 16S rRNA amplicon测序用于分析60名COVID-19患者的一年内肠道微生物组合的组成.
- 使用米利普莱克斯系统测量血清中细胞因子和化学因子水平.
主要成果:
- 严重的SARS-CoV-2感染,特别是肺炎,诱导了一种促炎性肠道微生物群 (例如,增加了Bacteroides, Faecalibacterium, Prevotella_9).
- 后COVID综合征与特定的细胞因子/化学因子以及促炎性肠道微生物转移相关.
- 功能分析揭示了与同乳酸发酵,酸,NAD救援和黄素生物合成途径的关联.
结论:
- 肠道微生物群,其代谢物和系统性细胞因子在塑造COVID后症状方面是密切相关的.
- 了解肠道微生物组在感染后并发症中的作用,可能会导致针对长期症状的新型治疗策略.
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