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Updated: Jun 25, 2025

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
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使用天然酵母和哺乳动物PrPP探索生物学的基础

Irina L Derkatch1, Susan W Liebman1

  • 1Department of Pharmacology, University of Nevada, Reno, NV 89557, USA.

Viruses
|May 25, 2024
PubMed
概括

子是采用异常形状的蛋白质,并将这些错误折叠的形状传递给其他蛋白质. 这种形状模板是子疾病的核心.

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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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