在患有牛皮病的患者中,COVID-19疫苗的有效性:基于人口的研究
Tal Gazitt1,2,3, Lihi Eder4, Walid Saliba3,5
1Carmel Medical Center, Rheumatology Unit, Haifa 3436212, Israel.
Vaccines
|May 25, 2024
概括
mRNA COVID-19 疫苗有效降低了牛皮病患者的SARS-CoV-2 感染和严重疾病. 免疫抑制剂,如乙坦塞普和甲铁酸,可能会增加感染风险.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 类风湿病学 类风湿病学
背景情况:
- 关于COVID-19疫苗在牛皮病 (PsD) 患者中的有效性数据有限.
- 了解疫苗的疗效和免疫抑制剂的影响对于在疫情期间管理PsD至关重要.
研究的目的:
- 评估mRNA COVID-19疫苗在预防SARS-CoV-2感染和PsD患者严重结局方面的有效性.
- 在这个队列中调查免疫抑制剂使用与COVID-19结果之间的关联.
主要方法:
- 采用了一个匹配的嵌套病例控制研究设计.
- 使用条件后勤回归,调整人口统计,并发病症和免疫抑制剂使用情况.
- 结果包括SARS-CoV-2阳性和严重的COVID-19 (住院或死亡).
主要成果:
- 至少一种mRNA疫苗剂量减少了SARS-CoV-2阳性 (OR=0.41) 和严重的COVID-19 (OR=0.15) 的风险.
- 三个疫苗剂量显示出更大的保护 (或感染=0.13,或严重疾病=0.02).
- 乙素和甲铁酸与SARS-CoV-2阳性风险增加有关 (分别为OR=1.58和OR=1.25).
结论:
- 在患有牛皮病的患者中,mRNA COVID-19 疫苗有效减轻感染和严重结果.
- 某些免疫抑制剂可能需要仔细考虑疫苗接种后感染风险.
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