粘膜粘合剂布德索尼德溶液用于治疗儿科埃索诺菲尔性食道炎
Antonio Spennacchio1, Antonio Lopalco1, Giuseppe Francesco Racaniello1
1Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
Pharmaceuticals (Basel, Switzerland)
|May 25, 2024
概括
开发了一种新的粘粘性口服布德索尼德溶液,用于治疗儿科异性食道炎. 这种配方增强了budesonide的功效.
科学领域:
- 胃肠病学 胃肠病学
- 药品制造 药品制造 药品制造
- 儿科医学 儿科医学
背景情况:
- 乙性食道炎 (EoE) 是一种影响食道的炎症状况,引起诸如消化不良和腹痛之类的症状.
- 目前的EoE治疗方法,如布松胺,已被批准用于成年人,但未批准用于儿童,因此需要替代儿科配方.
- 现有的布索尼德悬浮剂缺乏足够的食道停留时间来达到最佳的局部抗炎作用.
研究的目的:
- 开发一种临时的粘膜粘合性口服布德索尼德溶液,用于儿科异性食道炎治疗.
- 增强布索尼德在食道粘膜上的停留时间,以提高治疗疗效.
- 为儿科EOE提供稳定有效的新疗法选择.
主要方法:
- 使用氧-β-环氧和碳素甲基纤维素制备布德索尼德溶液.
- 在稳定性,度 (0.7毫克/毫升),质性和粘膜性质方面,布索尼德溶液的表征.
- 评估配方是否适用于食道中长时间的局部治疗.
主要成果:
- 一个稳定的budesonide口服溶液在0.7毫克/毫升成功地准备.
- 该配方表现出适合食道应用的rheological和粘粘性特征.
- 开发的溶液显示出具有延长局部抗炎作用的潜力.
结论:
- 对于儿科的EoE,即时制备稳定,粘粘性布德索尼德口服溶液是可行的.
- 这种配方提供了一种有前途的新治疗策略,用于治疗儿童的异性食管炎.
- 药剂师可以利用这种方法为儿科患者提供一种重要的新治疗选择.
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