在接受CAR-T细胞治疗的患者中神经认知功能的变化:登一座的山丘
Evlampia Strongyli1, Paschalis Evangelidis2, Ioanna Sakellari1
1Hematology Department and Bone Marrow Transplant (BMT) Unit, G. Papanicolaou Hospital, 57010 Thessaloniki, Greece.
Pharmaceuticals (Basel, Switzerland)
|May 25, 2024
概括
化学抗原受体T细胞 (CAR-T) 疗法对B细胞瘤有前途,但可能导致神经毒性. 本综述详细介绍了CAR-T后认知障碍的诊断方法和症状持续时间,强调需要进一步研究.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 化学抗原受体T细胞 (CAR-T) 疗法显著改善了复发/耐药B细胞瘤的结果.
- 细胞因子释放综合征 (CRS) 和免疫效应细胞相关的神经毒性综合征 (ICANS) 是显著的CAR-T并发症.
- 认知能力下降,包括注意力缺陷和执行功能障碍,是ICANS的一个普遍表现.
研究的目的:
- 对接受CAR-T治疗的人群认知障碍的诊断方法进行审查.
- 介绍有关输液后神经认知症状持续时间的最新数据.
- 突出研究CAR-T相关神经认知障碍的风险因素,发病,预防和治疗的需要.
主要方法:
- 对CAR-T患者认知障碍的诊断工具的文献综述.
- 分析关于神经认知症状时间进程的已发表数据.
- 综合目前对CAR-T相关神经毒性的理解.
主要成果:
- 在CAR-T治疗后,认知障碍很常见,影响注意力,命名,写作和执行功能.
- 为了评分ICANS的严重程度,存在各种各样的评分系统.
- 输注后症状持续时间的数据被介绍,表明了变化.
结论:
- 认知障碍是CAR-T疗法的关键挑战,需要标准化诊断方法.
- 进一步的研究对于理解和减轻神经认知不良事件至关重要.
- 改善神经毒性的管理对于优化CAR-T治疗疗效和患者结果至关重要.
关键词:
在CART-T中,我们可以使用CAR-T.在ICANS中,我们可以看到ICANS.无效性是一种无效性.认知 认知 认知淋巴瘤淋巴瘤是什么记忆 记忆 记忆 记忆 记忆骨髓瘤多样性 骨髓瘤多样性神经毒性的作用.更多相关视频
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
09:34Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
3.3K
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.3K
相关概念视频
01:24Parkinson's Disease: Treatment
1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
01:22Alzheimer's Disease: Treatment
1.3K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.3K