阿斯特拉加勒斯多糖的抗癌机制及其在癌症免疫治疗中的应用
Ziqing He1, Xiyu Liu1, Simin Qin1
1State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning 530021, China.
Pharmaceuticals (Basel, Switzerland)
|May 25, 2024
概括
来自A. membranaceus的阿斯特拉加勒斯多糖 (APS) 显示出显著的抗瘤作用,并增强了癌症免疫疗法. 这篇评论详细介绍了APS的细节.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 来自A. membranaceus的阿斯特拉加勒斯多糖 (APS) 是中国传统医学的关键组成部分.
- APS表现出抗瘤特性,并因其安全性而得到认可.
- 由于其免疫调节作用,人们对癌症免疫疗法的APS越来越感兴趣.
研究的目的:
- 审查APS的抗癌机制.
- 详细阐述APS在癌症免疫疗法和临床试验中的应用.
- 突出APS作为癌症治疗中的辅助疗法的潜力.
主要方法:
- 在过去二十年中,对癌症免疫治疗中APS的研究进行了全面的文献综述.
- 分析APS对免疫细胞,瘤微环境和癌细胞死亡的影响.
- 将APS与其他多糖类进行比较.
主要成果:
- APS表现出多方面的抗癌活动,包括免疫细胞调节,亡诱导和自.
- 与APS的联合治疗增强了治疗效果,并减少了副作用.
- 当与检查点抑制剂和癌症疫苗等免疫疗法相结合时,APS显示出有前途.
结论:
- 在癌症免疫治疗中,APS是一种有价值的辅助剂,具有广泛的临床应用.
- 了解APS的分子标可以带来改进的临床策略.
- 进一步的研究支持APS在癌症治疗中的未来临床使用.
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Tumor Immunotherapy
515
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
515
Cancer Vaccines
355
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
355
Cancer Survival Analysis
343
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
343
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


