基于亚麻油的油凝载体用于疏水性药物输送 - 物理化学和应用性质
Sonia Kudłacik-Kramarczyk1, Anna Drabczyk2, Alicja Przybyłowicz1,3
1Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, 8 Niezapominajek St., 30-239 Krakow, Poland.
Pharmaceutics
|May 25, 2024
概括
这项研究使用蜜蜂和Tween乳化剂开发了亚麻油油凝. 结果显示乳化剂类型影响了oleogel的水性,稳定性和结构,为材料设计提供了洞察力.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 合体和表面化学
背景情况:
- 油脂提供了传统脂肪的潜在替代品.
- 亚麻油和蜜蜂和Tweens等乳化剂是其关键成分.
- 了解乳化剂的作用对于定制油凝的特性至关重要.
研究的目的:
- 开发一种使用亚麻油和特定乳化剂合成油脂凝的方法.
- 研究乳化剂 (蜜蜂,Tween 20,Tween 80) 对油凝特性的影响.
- 分析合成的油脂凝的结构和物理化学特性.
主要方法:
- 合成具有不同乳化剂度的油凝.
- 表面湿度分析和表面能量测定.
- 福里埃变换红外 (FT-IR) 光谱学.
- 湿度测量 (相对和绝对).
- 光学显微镜和风湿学分析.
主要成果:
- 增加Tween 20降低了oleogel的水友性和潜在的表面能量,表明增强了稳定性.
- 与Tween 20相比,Tween 80对水友性产生了相反的影响.
- FT-IR和湿度分析证实了乳化剂对oleogel结构和功能组的影响.
- 显微镜分析表明,乳化剂中的更长的疏水尾带导致更密集的油凝结构.
结论:
- 乳化剂的选择显著调节了亚麻油油凝的物理化学和结构性质.
- 在Tween 20和Tween 80之间,对oleogel的水友性和稳定性表现出明显的影响.
- 该研究为通过控制的乳化剂使用来设计具有定制性能的稳定油脂提供了基础.
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