一遍又一遍 - - 在含有抗真菌剂的尿液中,Candida albicans的存活率

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Updated: Jun 27, 2026

08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

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Nevio Facchini^1,2, Lukas Wernli^1,3, Malte Rieken^2,4

¹Department of Biomedical Engineering, University of Basel, Hegenheimermattweg 167B/C, 4123 Allschwil, Switzerland.

Pharmaceutics

|May 25, 2024

概括

清真 (Candida albicans) 尿路感染 (UTI) 即使经过抗真菌治疗,也可能复发. 幸存的细胞具有较低的代谢活性,可能导致再生和感染复发.

科学领域:

菌类学菌类学是指菌类学.
传染性疾病传染性疾病
抗微生物耐药性抗微生物耐药性

背景情况:

经常出现的Candida albicans尿路感染 (UTI) 是很常见的.
目前使用的抗真菌药物,如可纳,是防真菌的,而不是杀菌的,导致治疗失败.

研究的目的:

了解Candida albicans在尿液中的长期生存和代谢活性,在最小抑制度 (MIC) 的抗真菌药物中.
为了确定导致Candida尿路感染复发的因素,尽管接受了治疗.

主要方法:

使用常规方法和异热微热度计 (IMC) 来监测存活率和代谢活性.
测量了Candida albicans的葡萄糖和蛋白质消耗.
研究了死去的Candida细胞对活细胞生长的影响.

主要成果:

在抗真菌药物的存在下,Candida albicans的生长速度降低 (48-88%) 和延迟阶段增加 (6-172小时).
相对于资源耗尽,新陈代谢活动峰值的延迟.
死亡的Candida细胞增强了人工尿中的活细胞的生长.

结论:

即使在抗真菌治疗期间,Candida albicans的复发也可能发生.
幸存细胞的低代谢活性,可能涉及自和胆胞形成,可能会导致复发.
了解这些机制对于改善Candida尿路感染治疗至关重要.

关键词:

在Candida albicans中使用.抗真菌剂是一种抗真菌剂.自自是自的过程.布拉斯托子的形成克拉米多子克拉米多子弗卢科纳尔 (Fluconazole) 是一种流氨酸 (Flucytosine) 是一种流氨酸.异热热量测量方法是异热量测量方法.复发和持续性的复发和持续性的复发.尿路感染尿路感染

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