优化纳米平台的挑战 用于在口腔腔中进行局部和系统的输送
Dorin Ioan Cocoș1, Olimpia Dumitriu Buzia1, Alin Laurențiu Tatu2,3,4
1Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" the University of Galati, 800008 Galati, Romania.
Pharmaceutics
|May 25, 2024
概括
这项研究探讨了口腔病理学的新型药物递送系统,包括微针和精油,以增强通过粘膜和通过皮肤给药,以改善口腔健康结果.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 口腔健康研究研究 口腔健康研究
背景情况:
- 目前在口腔病理学中药物管理面临着有效性和向性交付方面的挑战.
- 通过菌体和皮肤通道提供了在口腔中改善药物吸收的潜力.
- 精油具有双重益处,作为增强剂和治疗口腔疾病的治疗剂.
研究的目的:
- 研究创新的微针设计和精油增强剂,以改善口服药物输送.
- 审查口腔粘膜和现有的输送系统中药物释放的原则.
- 为优化治疗关节骨关节炎,神经病痛,口腔癌,牙周炎和牙周炎的局部药物输送.
主要方法:
- 开发新的形微针,以提高药物透率.
- 加入精油作为透增强剂,具有内在的口腔健康益处.
- 配制协同活性物质组合和共聚合物膜,用于直接固牙.
- 对控制释放系统的审查:快速溶解的薄膜,粘膜片,水凝,口内薄膜,复合晶片和智能药物.
主要成果:
- 拟议的形微针显示出改善跨粘膜药物递送的潜力.
- 精油显示作为双重作用剂的承诺,增强药物透和提供治疗效果.
- 同聚合物膜和协同组合为局部口服药物管理提供了新的方法.
- 优化的输送系统适用于各种口腔病理和一般口腔健康维护.
结论:
- 创新的药物输送系统,包括先进的微针和天然增强剂,如精油,可以显著改善口腔病理治疗.
- 该研究强调了局部药物输送在复杂的口腔疾病和口腔健康维护方面的潜力.
- 将天然产品整合到受控释放系统中,为更安全,更有效的口服疗法提供了一个有希望的途径.
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